2. GENERAL CHEMISTRY Ing. Blanka Macharáčková, Ph.D. Water and hydrogen bonding in water, properties, importance, examples, Ionic product of water, pH - definition , importance Solutions - basic properties of electrolytes solutions, strong, weak and slightly soluble electrolytes solutions, their definition, properties Theory of acids and bases, buffer systems, definition, biologically important buffer systems Theory of formation of compounds - activated complex and collision theory. Kinetics of formation od compounds- , reaction rate, Guldberg-Waage law, catalysis, principles of enzymatic kinetics. 4. BIOINORGANIC CHEMISTRY Ing. Blanka Macharáčková, Ph.D. Classification of elements in accordance with their role in living systems - structural elements, macroelements, their representatives and importance Trace elements - their classification, concept of essentiality of trace elements. 6. BIOINORGANIC CHEMISTRY Ing. Blanka Macharáčková, Ph.D Toxic and hazardous elements, their definition and representatives Biologically important elements in different groups of periodic system - medically important and some commonly known and interesting compounds of these elements. 8. BIOORGANIC CHEMISTRY Ing. Blanka Macharáčková, Ph.D. Amino acids and proteins. Distribution, structure, important reactions, solubility and influencing of solubility of these substances, meaning for living matter. 10. BIOORGANIC CHEMISTRY MVDr. Michaela Králová, Ph.D. Monosacharides, disacharides, polysacharides and their derivatives. Important reactions of sacharides, meaning for living matter. 12. BIOORGANIC CHEMISTRY MVDr. Michaela Králová, Ph.D. Fatty acids and lipids - their classification, their composition, important reactions, meaning for living mater. Vitamins and hormones, their classification, basic chemical structure. Praktical lessons 1.-2. Safety of the laboratory work, laboratory glass, basic calculations 3.-4. Basic laboratory work - measuring of mass, working with pipettes, statistical evaluation 5.-6. Titration + determination of unknown volume 7.-8. Titration + determination of unknown amount of a solid sample 9.-10. pH measurement 11.-12. Credit test 13. Registration of credit
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From the point of view of content there are four basic parts of the discipline: 1. Principal chemical laws and rules concerned with the structure and properties of substances and their applications with regard to the biological reactivity of substances. 2. Basis of bio-inorganic chemistry dealing with biological significance and functions of important ions and substances (structural elements, macro-elements, trace elements). Bio-cycles of the most important structural elements. 3. Basis of bio-organic chemistry dealing with relations between the structure and reactivity of biologically significant organic substances. Systematics of important organic substances especially with regard to needs of subsequent disciplines e.g. biochemistry. 4. Principles and state of the art of analytical methods both classical and instrumental used in laboratories working at the field of veterinary hygienic supervision, food and feed-stuffs analysis.
Theoretical knowledge The student: - knows the basic principles of behaviour of aqueous solutions and reactions that take place in them and factors that affect them, - is able to name the elemental composition of living matter, knows the classification of elements according to their significance regarding both the content and the function in the organism, - can explain and describe the basic building blocks of the bioorganic composition of living matter in terms of both simple chemical composition and structure, important reactions and basic functions of groups of substances (amino acids, proteins, carbohydrates, fatty acids and fats, nucleic acids, vitamins and hormones) Practical skills The student: - can prepare accurate concentrations of solutions in conjunction with modern dosing methods of liquids, - can extract an analyte according to the type of matrix containing the analyte, - can subsequently dilute the extracted analyte as needed depending on the analytical method used, - knows the basic principles of instrumental chemistry, the correct use of calibration procedures and the use of these calibrations for ion measurements. Competences The student is able to: - choose the correct procedure when preparing solutions or obtainin analytes, - test your own work and the work of the group using accuracy and correctness and thereby work to improve its quality, - use knowledge of the behaviour and function of basic substances in living matter (organic an inorganic) in other related subjects.
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