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Lecturer(s)
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Matalová Eva, prof. RNDr. Ph.D.
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Stehlíková Šárka, MVDr. Ph.D.
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Veselá Ivana, MVDr. Ph.D.
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Kytková Lucia, MVDr.
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Course content
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Lectures: Physiology as a discipline, homeostasis, health/illness Cell as the basic functional unit, stem cells Cell-cell communications Inner environment - determinants Inner environment - regulations Blood - plasma Blood - erythrocytes Blood - thrombocytes Blood - leukocytes Immune system - non-specific immunity Immune system - specific immunity Metabolism Stress, pain Physiology I - overview Practical lessons: Introduction, methods in physiology, safety rules, GLP 3R - in vivo/in vitro/explant cultures Cell homeostasis, cell cycle Stem cells, diversity of cells and their functions Inner environment - electrolytes Inner environment - ABB Blood plasma - function of components Blood - erythrocytes (1) Blood - erythrocytes (2), thrombocytes Blood - leukocytes Blood - immune system Physiological interactions within the immune system Energetic metabolism Credit procedure
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Learning activities and teaching methods
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Lectures, Seminars, Laboratory and desk-based work
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Learning outcomes
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Physiology I and Physiology II are integrated segments anchored within 2 semesters. Physiology I is focused on homeostasis, cell physiology, inner environment, extracellular fluids, basic principles of regulations, metabolism, stress and pain. The practical courses have a direct continuity with the lectured topics and are designed with an emphasis on hands-on experience expanded by interactive forms of education to reinforce the skills and knowledge. Each practical course is a complex unit that is terminated by protocol elaboration aimed at the interpretation of results and relevant conclusions.
1) theoretical knowledge The student is able/knows/understands: - basic principles of homeostasis, homeostatically regulated mechanisms and functions of organs at a cellular level, functions of components of both the blood plasma and blood elements, local and systemic levels, basic mechanisms and interactions within the immune system, physiologically important/relevant basic biochemical principles, - regulatory mechanisms working at the cell, tissue and organ level with an interpretation of important physiological functions including "fragile points" associated with pathophysiological and clinical issues. 2) practical skills The student is able to: - work with tissue explants, evaluate functions of cells (e. g. proliferation) in tissue context, stabilize blood samples, prepare them for qualitative and quantitative analyses focused on parameters of the inner environment and blood elements, - obtain relevant data from the analyses, to interpret the data in the context of physiological functions and to understand the importance of such parameters also towards pathological physiology, - create a solid scaffold for a cognitive structure gradually implementing knowledge in the axis: physiology - pathophysiology - pharmacology - clinics to integrate theoretical and practical pieces of knowledge (skills) to use them independently (updates, upgrades). 3) competences The student is competent: - to enrol on Physiology II
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Prerequisites
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unspecified
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Assessment methods and criteria
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Written credit test,
Credit requirements: - meeting qualification requirements (written mini-tests, oral discussion, final credit test), - elaboration of protocols based on obtained results.
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Recommended literature
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