|
Lecturer(s)
|
-
Jelinek April, MVDr.
-
Hořín Petr, prof. MVDr. CSc.
-
Stejskalová Karla, MVDr. Ph.D.
|
|
Course content
|
Lectures: Domestic animals: genetics of domestication. Breeding of domestic animals: theoretical principles. Selection and selective breeding: methods and applications. Breeding value and its estimation. Inbreeding and heterosis in domestic animal breeding. Domestic animal genomes. Genomic approaches to identifying practically important traits in domestic animals and to estimating breeding value. Mutations and their effects. Cytogenetics in veterinary medicine. Inherited diseases in domestic animals. Birth defects in domestic animals - terminology, causes, mechanisms, practical importance. Genetic variation in resistance/susceptibility to disease: breeding for disease resistance in domestic animals. Genetics and reproduction. Fertility as a genetic trait, selection for improved fertility. Biotechniques in animal breeding and their genetic aspects. Principles of cloning, applications in domestic animals. Pharmacogenetics and pharmacogenomics: genetic variation in reaction to drugs. Applications in veterinary medicine and in drug production. Principles of genetic manipulations, possible applications. Practical lessons: Modes of inheritance in animals, pedigree analysis. Inherited disorders and congenital developmental defects in domestic animals - causes and differential diagnostics. Applied calculations in veterinary genetics: population genetics, inbreeding. Basic methods of molecular biology in veterinary medicine and their use for diagnostics. Parentage testing. Inherited diseases and congenital developmental defects in farm animals, dogs, and cats.
|
|
Learning activities and teaching methods
|
|
Lectures, Seminars
|
|
Learning outcomes
|
The objective is to provide information on practical applications of genetics to veterinary medicine and animal breeding. In the context of theoretical principles of animal breeding, the following topics are presented: inherited diseases and congenital anomalies of domestic animals, genetics of disease resistance, principles of genetic diagnostics, new trends in genetics, and application of modern genomic tools to address complex issues in biomedicine.
1) theoretical knowledge Students are able to define, characterize, explain, and interpret the current knowledge of genetics and genomics and its application to different areas of veterinary medicine. 2) practical skills Students are able to recognize when to express a suspicion about possible genetic causes of a pathological condition. They are able to identify the major modes of inheritance of domestic animal disease, they can interpret the results of laboratory and/or other genetic analyses for him/herself as well as for their clients. They are able to perform and interpret basic genetic calculations used in animal breeding (coefficient of inbreeding). They can identify the most common inherited diseases of domestic animals. 3) competences Students are able to use the acquired knowledge and skills to decide independently about further steps in case of a pathological condition with a possible genetic cause. They are able to decide whether they can address such an issue on their own or whether they should refer the client to a specialist.
|
|
Prerequisites
|
unspecified
|
|
Assessment methods and criteria
|
Written exam, Written credit test
1) credit: written test assessing whether the student is able to reflect the contents of practicals in a form of calculations or as a brief summary of a given topic. Possible outcomes: passed/non-passed. 2) exam: written test composed of two parts. A multiple-choice test (MCT) assesses particular knowledge, while a review of a given topic assesses students´ overview of a broader topic defined by lectures and their capability of presenting the topic in a structured and selective way. Evaluation: review: yes/no, MCT: numbers of points with a minimum number defined. Outcomes: passed (review: yes; MCT: minimum number of points), grade defined by the number of points for MCT). All other results: non-passed.
|
|
Recommended literature
|
-
F. W. Nicholas. Introduction to veterinary genetics, 3rd Ed..
|